THE 2-MINUTE RULE FOR ONOLIDINE

There's a launch of norepinephrine from the descending inhibitory bulbospinal neurons that binds to alpha-two-receptors from the dorsal horn to lessen afferent discomfort transmission and produce analgesia. Hence, drugs like clonidine that focus on alpha-2 receptors can affect the transmission of pain.Clonidine is a long-time period medication. I